Endocrine Abstracts

Introduction: Acute pancreatitis is an inflammatory disease of the pancreas that can lead to necrosis of the pancreas and if infected could lead to multi-organ failure. Common cause of acute pancreatitis are gallstones and excess alcohol consumption. Hypertriglyceridemia is becoming an increasing cause of acute pancreatitis and is diagnosed with serum triglyceride levels >1.7 mmol/l. It is associated with high morbidity and mortality.Case presentatio...

Introduction: Pituitary adenomas are benign tumours of the pituitary gland with an estimated prevalence rate of approximately 17%. Around 1 in 600 people have macroadenoma (>1cm) that can present with variety of visual problems classically as bitemporal hemianopia due to compression of the optic chiasm.Case presentation: 50-year-old male was admitted with 3months history of worsening headache and 4months of visual disturbances. Initially he was seen ...

Introduction: An adrenal incidentaloma is an adrenal mass lesion greater than 1 cm in diameter, which is incidentally discovered by radiological investigation. The prevalence of adrenal incidentalomas increases with age, increasing to around 3% at aged 50years and 10% in the elderly. The majority of these lesions are benign >80%. Adrenal incidentalomas fall into one of three categories: Non-functioning tumours: these lesions are benign e.g. adenomas, adrenal cysts, haemato...

Introduction: This case series consist of three brothers who are aged 24, 27 and 28. The eldest brother was diagnosed with CAH at 18 days when he presented with poor weight gain, vomiting and persistent jaundice with hyponatraemia. The parents received genetic counselling for the next two pregnancies and all three children were managed with hydrocortisone and fludrocortisone maintainence therapy. They were closely monitored for their growth rates, signs of precocious puberty a...

Introduction: Ongoing advancements in the treatment of malignancy has witnessed an increasing use in new immunotherapies, including immune checkpoint inhibitors. Immune-related endocrinopathies affect around 10% of patients treated with checkpoint inhibitors. Common endocrinopathies include thyroid disease and hypophysitis.Aim: Baseline monitoring test for endocrine disorder in patients started on immunotherapy for cancer treatment and implementation of ...

Introduction: There are multiple causes of delayed puberty including constitutional delay in growth and puberty, chronic diseases, hypothyroidism, and pituitary tumours (e.g. craniopharyngioma). Delayed puberty due to macroprolactinoma is rare.Case Presentation: A 23-year-old male was reviewed in the Endocrine clinic after presenting with headaches and generally feeling unwell. Blood test showed a high prolactin level of 84637, low FT 7.7, low testostero...

Background: The causes of thyrotoxicosis include hot and Graves disease. Graves’ disease can be associated with Graves eye disease, and thus have a psychological impact on the patient. The treatment of thyrotoxicosis includes medical therapy, surgical therapy, and radioiodine treatment. Treatment of thyroid eye disease includes both medical and surgical therapy in a multidisciplinary setting. Medical treatment using steroids may worsen hyperglycaemia in patients with exis...

Background: Patients receiving radiotherapy for residual or recurrent pituitary adenoma require regular surveillance for the development of anterior pituitary axis deficit. Whilst the sequelae of hypopituitarism post cranial irradiation is well recognized, there are relatively varied incidences of new onset hypopituitarism post-conventional radiotherapy, reported in the literature. We aimed to investigate timing and frequency of the individual axis deficits in adults who have ...

Background: Acute pancreatitis is both a medical and surgical emergency. Common causes of acute pancreatitis include gallstones and alcohol. Hypertriglyceridemia-induced pancreatitis is rare (1-4%); here we discuss management of 5 cases of hypertriglyceridemia-induced pancreatitis.Case-1: 37-year-old female presented to A&E with epigastric pain radiating to back and vomiting. Blood test showed raised amylase, triglyceride 81.6 and cholesterol 6.1. CT...

Introduction: Thyroid cancer is one of the common malignancies diagnosed in pregnancy and the management of thyroid nodules in pregnancy is the same as in non-pregnant patients. Ultrasound thyroid and FNA are necessary in the investigations of any thyroid nodule.Case presentation: A 39-year-old woman of Eastern European descent presented to the joint obstetric-endocrine clinic complaining of dysphagia and swollen neck at 34 weeks gestation. Her past medi...